Investigation on baicalin‐loaded chitosan film crosslinked by graphene oxide and its biocompatibility

Chitosan has good biocompatibility, in vivo biodegradability and certain physiological activity, which can be used as a drug carrier to stabilise protect components, causing the promotion of absorption controlling release. Using graphene oxide (GO) cross-linking agent, functional groups its lamellar structure interact effectively with chitosan molecules, leading enhanced mechanical properties optimize controlled drug-release behaviour. GO/chitosan composite films were prepared by solution mixing method various GO content exhibit many hydrogen bonds between chitosan. There no obviously agglomerated particles surface films, observed cross section films. Differential thermal analysis (DTA) indicated that addition increased stability film. The baicalin-loaded GO/Chitosan also exhibited pH dependent release behaviour, an increasing amount rate at lower medium. In addition, result biological evaluations showed had cytocompatibility vitro histocompatibility appropriate concentrations. This investigation offered new pH-dependent potentially applied for tumour atherosclerosis treatment.